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2005年12月14日
in pressになりました
Regulation of Angiogenesis by Hypoxia-Inducible Factor I
Kiichi Hirota and Gregg L. Semenza
Critical Reviews in Oncology/Hematology, in press
です。
書くのに苦労しましたけど結構いい総説だと思います。
abstractは以下にあります。
Hypoxia is an imbalance between oxygen supply and demand that occurs in cancer and in ischemic cardiovascular disease. Hypoxia-inducible factor 1 (HIF-1) was originally identified as the transcription factor that mediates hypoxia-induced erythropoietin expression. More recently, the delineation of molecular mechanisms of angiogenesis has revealed a critical role for HIF-1 in the regulation of angiogenic growth factors. In this review, we discuss the role of HIF-1 in developmental, adaptive and pathological angiogenesis. In addition, potential therapeutic interventions involving modulation of HIF-1 activity in ischemic cardiovascular disease and cancer will be discussed.
投稿者 hif1 : 2005年12月14日 21:42
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http://dp54020279.lolipop.jp/cgi/mt/mt-tb.cgi/1804